News
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Call for Nominations: 2025 糖心Vlog官方 Prize Student Scholar
Nominations for the 2025 糖心Vlog官方 Prize Student Scholar are invited now through June 27, 2025. Candidates for the 糖心Vlog官方 Prize Student Scholar are graduate students in biomedical sciences at 糖心Vlog官方 (Ph.D. or M.D./Ph.D. track) who have completed the qualifying exam and have at least one year… Read MoreJun. 10, 2025
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CSB Spotlight: Prashant Singh, Iverson Lab
Prashant Singh, Senior Research Associate, Iverson Lab Prashant Singh, is a Senior Research Associate in the Iverson Lab.聽He’s getting used to the spotlight from his recent appearance on the YouTube channel SmarterEveryDay. However, he’s still the down-to-earth Prash, as he’s known… Read MoreMay. 30, 2025
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Redefining聽synaptic architecture: nanoblocks as key organizing units in the postsynaptic density
Cellular function relies on the nanoscale organization of molecular components. Pre-synaptic, post-synaptic and cell adhesion proteins within the synapse are carefully organized in nanostructures to facilitate the transmission of information between neurons, a process which is essential for synaptic plasticity, learning and memory formation. However, the precise structural arrangement of… Read MoreMay. 9, 2025
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CSB Research Spotlight: Wankowicz Lab – How protein movement influences function
Understanding how proteins get from point A to point B is top of mind for Stephanie Wankowicz, assistant professor of molecular physiology and biophysics. The Wankowicz lab conducts research on how entropy, a measure of the tendency toward disorder or randomness within a system, shifts when a protein… Read MoreApr. 28, 2025
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CSB Spotlight: Katherine Stefanski, Sanders Lab
Katherine Stefanski, PhD, Sanders Lab Sanders Lab Postdoc Katherine Stefanski’s lab motto might be “a place for everything and everything in its place.” Outside the lab she likes to wreak a bit of havoc in Smashville! That is, when it doesn’t get in the way of a… Read MoreApr. 25, 2025
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From activation to repression: decoding the impact of PPAR纬 ligands on ligand-binding domain conformation
Nuclear receptors (NRs) are a group of transcription factors that control gene expression in response to endogenous metabolites and synthetic ligands. Ligands bind the C-terminal ligand-binding domain (LBD) of NRs which is widely believed to alternate between transcriptionally active and repressive states and be stabilized upon ligand binding. Various X-ray… Read MoreApr. 11, 2025
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CSB Spotlight: Areetha D’Souza, Chazin Lab
Areetha D’Souza, PhD, Research Instructor, Biochemistry and Chazin Lab Areetha D’Souza is a research instructor in the Department of Biochemistry and the Chazin Lab. With a diverse scientific background centering on NMR and cryo-EM, she still has time for the finer things in life鈥攅specially… Read MoreMar. 21, 2025
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CSB Research Spotlight: X-ray Crystallography – Paving the way for 鈥榟ypoallergen鈥 treatments against peanut allergies
The chart on the left shows the panel of peanut-reacting antibodies that the Smith lab isolated from food-allergic patients, indicating that most of the antibodies bound two peanut proteins, Ara h 2 and Ara h 6. The chart in the middle shows a subset of those antibodies separated… Read MoreMar. 7, 2025
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CSB Research Spotlight: Sanders Lab – New mechanisms that cause irregular heartbeat
In a recent collaboration with researchers at Northwestern University, newly-minted PhD Kathryn Butcher (Brewer) and Professor of Biochemistry and Vice Dean of Basic Sciences Chuck Sanders found that, for people with long QT syndrome, a heart condition that causes an irregular heartbeat, a more tailored approach to treatment… Read MoreMar. 3, 2025
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Greater than the sum of its parts: the role of VARP-SNX27 binding in endosomal 鈥渟upercomplex鈥 formation
In cells, multi-subunit coat protein complexes are responsible for coordinating the transport of transmembrane proteins and lipid cargo between membranes. At the endosome, cargo trafficking is mediated by retromer, a heterotrimer composed of VPS26, VPS29, and VPS35. Retromer serves as a 鈥渕aster regulator鈥, recruiting machinery to help deform the membrane… Read MoreFeb. 14, 2025