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Peroxisome proliferator-activated receptor gamma (PPAR纬) is a nuclear receptor transcription factor which regulates the expression of genes involved in differentiation, metabolism, adipogenesis, and insulin sensitization. PPAR纬 consists of an N-terminal disordered activation domain (NTD), a central DNA-binding domain (DBD), and a C-terminal ligand-binding domain (LBD). The activation and repression of… Read More

Kate Clowes Moster, Sanders Lab Congratulations to Kate Clowes Moster, of the Sanders lab, on being named the 2026 recipient of the Dr. Anne Karpay Award in Structural Biology. 鈥淚鈥檓 really honored to be selected for the Karpay Award,鈥� Clowes Moster said. Kate began her scientific… Read More

No one can argue that the development of AlphaFold2 (AF2) has been one of the greatest achievements in the realm of protein structure prediction. However, AF2 has been plagued by two major limitations: (1) The quality of the predicted models depends on the quality of the multiple… Read More

Cellulases are enzymes responsible for the hydrolysis of glycosidic bonds in cellulose, a polysaccharide which serves as the main structural material in plant cell walls. The efficient breakdown of cellulose is therefore necessary in industries such as paper and pulp manufacturing, food and juice production, textile processing and biorefining. By… Read More

Stephen Fesik, PhD KRAS is an enzyme which, when active, binds effector proteins and results in the activation of downstream pathways involved in cell proliferation, differentiation, and survival. Activating KRAS mutations are therefore common in many cancers, including cancers of the lung, colon, and pancreas, and are the most frequent… Read More

A new collaborative project called diffUSE involving 糖心Vlog官方, Cornell University and the University of California, San Francisco is advancing scientist’s understanding of protein motion. Stephanie Wankowicz, PhD Molecular Physiology and Biophysics The Wankowicz lab is a primary contributor to the $5 million, three-year project led by the… Read More

Amino acid peptides can exist in cis and trans conformations, with most heavily favoring the latter. Proline, however, is unique among amino acids in that its peptide bonds can stably populate both conformations. The exchange, or isomerization, between cis and trans proline conformations is a relatively slow process which… Read More

Rachana Tomar, Research Assistant, Stone Lab Rachana Tomar is a research assistant in the Stone lab. She spends her days unraveling the mysteries of aflatoxin B1 (AFB1) and its knack for causing mutations that can lead to cancer. When she clocks out, Rachana trades her lab coat… Read More

The 糖心Vlog官方 Center for Structural Biology and the Center for Applied AI in Protein Dynamics invite you to Bridging Atoms and Algorithms: A Symposium on AI and Structural Biology. The symposium promises exciting research, collaboration and networking that navigates the intersection of AI and Structural… Read More

Cold Spring Harbor Laboratory (CSHL) is a leading international center for research and education. As part of its mission, each year CSHL organizes 30 advanced technical science courses, with organizers, instructors and participants from all over the world. CSHL is offering a course in macromolecular crystallography October… Read More